News & Publications

$750,000 Grant to Improve Understanding of Nerve-Muscle Communication at PSC, Pitt

PSC Figure

View from the inside of a nerve cell, from the PSC/Pitt team's earlier simulations. The synapse and the muscle cell are not pictured, but would be below the nerve cell’s cell membrane, at the bottom. In the frog neuromuscular junction (A), neurotransmitter-containing packets (vesicles) waiting to be dumped into the synapse are arranged in two rows. (Vesicles are in red, calcium channels below the vesicles are small red dots, and the calcium ions diffusing in the nerve terminal are represented as small blue or yellow dots.) In the mouse (B), the vesicles are organized in clusters that each contain two vesicles. Simulations on Bridges showed that the frog system, when rearranged in clusters like the mouse, began to behave like the mouse NMJ.

Lab, Computer Experiments to Improve Simulations of Signaling between Nerve and Muscle cells, Offering Clues to Treating a Type of Neurological Disease

Oct. 5, 2020

A new $750,000 grant from the National Science Foundation will continue a lab-computer collaboration that accurately simulated communications between nerve cells and muscle cells. The project has immediate applications in treating a type of neurological disease called Lambert-Eaton Myasthenic Syndrome (LEMS). It also offers fundamental insights into how nerve cells communicate with muscle cells in health and disease.

Early User Program for Bridges-2

Sept. 24, 2020

PSC is excited to announce the Early User Program for Bridges-2, our newest computational research platform. Bridges-2 will provide transformative capability for rapidly evolving, computation-intensive and data-intensive research, creating opportunities for collaboration and convergence research. It will support both traditional and non-traditional research communities and applications. Bridges-2 will integrate new technologies for converged, scalable HPC, machine learning and data; prioritize researcher productivity and ease of use; and provide an extensible architecture for interoperation with complementary data-intensive projects, campus resources, and clouds.

Please see https://www.psc.edu/bridges-2/eup-apply for application instructions and http://www.psc.edu/bridges-2 for project details and updates.

If you have any questions or need help completing the application process, please do not hesitate to contact us via email at bridges2@psc.edu.

HuBMAP Inaugural Data Release: Detailed Anatomical Data about Seven Human Organs for Scientists, Public

Hubmappromo

 

Sept. 1, 2020

HuBMAP (the Human BioMolecular Atlas Program) has released its inaugural data for use by the scientific community and the general public. Included in this release are detailed, 3D anatomical data and genetic sequences of healthy tissues from seven organ types, at the level of individual cells as well as many bulk tissue datasets. HuBMAP’s ultimate goal is to provide the framework required for scientists to create a 3D atlas of the human body. HuBMAP’s tools and maps are openly available for research to accelerate understanding of the relationships between cell and tissue organization and function, as well as human health. PSC is a leading member of the HuBMAP Integration, Visualization, and Engagement (HIVE) Collaboratory.

You can get more information about the HuBMAP data release here. Visitors can find the data here.

Unequal Neutron-Star Mergers Create Unique “Bang” in Bridges Simulations

Slower and Noisier

Aug. 3, 2020

It seems strange to talk about “quiet” versus “noisy” collisions of neutron stars. But many such impacts form a black hole that swallows all but the gravitational evidence. A series of simulations using PSC’s Bridges platform and other supercomputers by a Penn State scientist suggested that, when the neutron stars’ masses are different enough, the result is far noisier. The model predicts an electromagnetic “bang,” which isn’t present when the merging stars’ masses are similar, that astronomers should be able to detect.

 

 

 

 

 

 

 

 


Above: a neutron star is ripped apart by tidal forces from its massive companion in an unequal-mass binary neutron star merger (left). Most of the smaller partner’s mass falls onto the massive star, causing it to collapse and to form a black hole (middle). But some of the material is ejected into space; the rest falls back to form a massive accretion disk around the black hole (right). From Figure 4 in Accretion-induced prompt black hole formation in asymmetric neutron star mergers, dynamical ejecta and kilonova signals. Bernuzzi S et al., Monthly Notices of the Royal Astronomical Society, online June 2020.

NSF Funds Neocortex, a Groundbreaking AI Supercomputer, at PSC

The National Science Foundation Awards $5 million to the Pittsburgh Supercomputing Center to Build Neocortex, an AI Supercomputer that Will Introduce Revolutionary Technologies

June 9, 2020

A $5 million National Science Foundation (NSF) award will allow the Pittsburgh Supercomputing Center (PSC) to deploy a unique high-performance artificial intelligence (AI) system. Neocortex will introduce fundamentally new hardware to greatly speed AI research. PSC, a joint research organization of Carnegie Mellon University and the University of Pittsburgh, will build the new supercomputer in partnership with Cerebras Systems and Hewlett Packard Enterprise (HPE).

PSC Bids Farewell to Rich Brueckner

Saying Goodbye to Our Friend

 

We at PSC are deeply saddened by the passing of Rich Brueckner, leader of insideHPC. For many years, Rich drew on his industry-wide insights to communicate the impact of our field, its companies, and its contributors. Rich’s enthusiasm and optimism drove the countless interviews he conducted for insideHPC. For those of us who had the privilege of working with him, what we will remember most are his good nature and compassion, exemplified by his support for local animal shelters. HPC events won’t be the same without Rich and his iconic red hat. He will be sorely missed. 

 

We would like to extend our deepest and most sincere condolences to Rich’s family, friends, and close colleagues. We will aim to rejoice in the positive impact he had and the memories of good moments together.

 

We invite all to join Rich’s friends and colleagues from the HPC community in Rich’s Celebration of Life, a Zoom meeting that will take place on Tuesday, June 2, from 4-6 pm EST. More information available here

 

We can honor his life by continuing his legacy and supporting some of the causes that were close to his heart. 

 

 

Link to obituary here.

 

Rest in peace dear friend.

Making Data Lemonade

Lockdown status in each state versus number of COVID-19 cases, March 20-29, 2020. Visual shows the date of lockdown in each state by turning gray. The numbers on top of the states indicate the number of new cases from that state that day. Credit: Breanna Franchak, Pine Richland High School, and Cassidy Power, University of Pittsburgh.

COVID-19 Pandemic, Isolation an Opportunity for Pittsburgh-Area High Schoolers to Learn Data Science

It begins with a data-driven discussion of the national plan to reopen safely. Brian Macdonald, director of data science at a leading healthcare data analysis company, reviews the plan to phase out the quarantine based on continuous two-week decreases in COVID-19 cases in a given state.

His audience is not who you might expect. Listening in, via teleconference, are about 20 students from high schools across the Pittsburgh area.

PSC Media Contacts

Media / Press Contact(s):

Kenneth Chiacchia
Pittsburgh Supercomputing Center
chiacchi@psc.edu
412-268-5869

Vivian Benton
Pittsburgh Supercomputing Center
benton@psc.edu
412.268.4960

Website Contact

Shandra Williams
Pittsburgh Supercomputing Center
shandraw@psc.edu
412.268.4960

Use of PSC materials: To request permission to use PSC materials, please complete this form.

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