Pittsburgh Supercomputing Center
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Science for Lunch
Friday, May 17, 2013, 12:00pm - 01:00pm

Dr. Sudhir Pathak, from the Learning Research and Development Center at the University of Pittsburgh, will give a talk titled "High Definition Fiber Tracking – A Pipeline of Computational Methods to Map White Matter Tracts and Support Clinically Viable Tract Analysis."


Abstract: In this seminar, I will present a Diffusion MRI based novel technique, High Definition Fiber Tracking (HDFT), to trace white matter fiber pathways in the Human Brain. Mapping of white matter tracts in the Normal Human Brain and the Pathological Brain has great scientific and clinical potential. The HDFT technology can be used to diagnose Traumatic Brain Injury in soldiers, sports persons or other patients who have suffered from concussions. Current methods have difficulties providing reliable single subject maps that accurately reflect established tract structures. Our approach improves accuracy by a process of full pipeline optimization across the stages of scanning, reconstruction, fiber tracking, and quantification. Accuracy depends nonlinearly on the interactions of these stages. We use quantitative accuracy metrics on established tracts to identify the optimal methods involved in the pipeline. The current components include Diffusion Spectrum Imaging (257d 3T 32 channel coil), Generalized Q‐sampling imaging (Yeh et al 2010), quantification with directional axonal volume (dAV) of the anisotropic water, subvoxel dAV based fiber tracking with Finite Element Method interpolation and quantification of tract spectra. This pipeline has identified existing and novel cortical tracts confirmed through Klinger cadaver dissection (Wang et al 2012). Neurosurgeons have found the images informative in clinical cases (Fernandez‐Miranda et al 2012). In TBI patient populations this approach shows significant differences compared to controls providing tract integrity quantification on individual patients (Shin et al 2012). Future directions included reduced scan time, patient tract integrity report generation, and iPad based case tract reviews.

Location : Room 103, Pittsburgh Supercomputing Center, 300 S. Craig St.